NEIL1

Across TCGA pan-cancer cohorts, NEIL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NEIL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NEIL1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEIL1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and BRCA are the cancer types where NEIL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEIL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.540	<.001	10	view →
LUSC	All	All	−0.808	<.001	6	view →
BRCA	Female	II,III,IV	−0.729	<.001	6	view →
COAD	All	All	+0.392	.002	6	view →
HNSC	All	II,III,IV	−0.383	.002	6	view →
KIRC	All	III,IV	−0.350	.010	5	view →
LIHC	All	All	+0.330	<.001	5	view →
LUAD	Male	All	−0.615	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NEIL1–KICH

Open the KICH breakdown →