NEIL1

Across TCGA cell cohorts, NEIL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible NEIL1-associated genes across cancer lineages are AVP, ELOA3DP, and IL17F. Each is linked with NEIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEIL1-to-partner and partner-to-NEIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by NEIL1-low versus NEIL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL1→partner) and Y-score (partner→NEIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.085	+5.217	<.001	<.001	3	2
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1
OVARY	IL17F →	+0.038	+4.095	.001	.003	3	1
OVARY	FAM71C →	+0.011	+3.938	.009	.005	3	1
OVARY	PRR23C →	+0.009	+3.990	<.001	.003	3	1
OVARY	C4orf51 →	+0.130	+3.990	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

AVP by NEIL1 expression — LARGE_INTESTINE

Explore this box plot interactively →