NEGR1

Across TCGA cell cohorts, NEGR1 mutation is significantly associated with the mutation status of many other genes, with 3,939 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEGR1-associated genes across cancer lineages are PRKD1, DBT, and OR51G2. Each is linked with NEGR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NEGR1-to-partner and partner-to-NEGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKD1 grouped by NEGR1-low versus NEGR1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEGR1→partner) and Y-score (partner→NEGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRKD1 →	+4.807	+4.807	.008	.008	1	4
SKIN	DBT →	+5.824	+5.824	.002	.002	1	4
LUNG_NSCLC_LUAD	OR51G2 →	+4.303	+4.000	.001	.001	1	3
LUNG_NSCLC_LUAD	NRXN1 →	+1.792	+3.667	.006	.006	1	3
LUNG_NSCLC_LUAD	FAM47B →	+3.396	+4.078	<.001	<.001	1	3
LUNG_NSCLC_LUAD	OR2T6 →	+2.718	+3.604	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,939 associations by consensus.

PRKD1 by NEGR1 expression — STOMACH

Explore this box plot interactively →