NEFM

Across TCGA patient cohorts, NEFM mutation is significantly associated with the RNA expression of many other genes, with 5,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEFM-associated genes across cancer lineages are MTFP1, DCTN6, and CEP78. Each is linked with NEFM in more than 3 cancer types. Because this analysis shows association rather than direction, both NEFM-to-partner and partner-to-NEFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFP1 grouped by NEFM-low versus NEFM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFM→partner) and Y-score (partner→NEFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFP1 →	+0.467	+2.673	<.001	<.001	3	4
UCEC	DCTN6 →	+0.450	+2.055	<.001	<.001	3	4
UCEC	CEP78 →	+0.558	+2.544	<.001	<.001	3	4
COAD	ELP5 →	+0.378	+2.276	.003	.005	3	4
SKCM	ARHGAP19 →	+0.667	+1.999	<.001	.009	3	3
COAD	NANS →	+0.444	+3.498	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,606 associations by consensus.

MTFP1 by NEFM expression — UCEC

Explore this box plot interactively →