NEFM

Across TCGA pan-cancer cohorts, NEFM RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NEFM’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NEFM RNA is repressed in tumor relative to normal tissue. In most cancer types NEFM is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRC are the cancer types where NEFM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEFM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.908	<.001	10	view →
KICH	Male	All	−2.094	<.001	9	view →
KIRC	Male	II,III,IV	−0.970	<.001	9	view →
HNSC	All	II,III,IV	+1.399	.001	8	view →
READ	All	All	−1.007	<.001	7	view →
STAD	All	All	−0.860	<.001	7	view →
UCEC	All	All	−1.180	<.001	6	view →
PRAD	All	All	−0.814	<.001	2	view →
LUSC	All	All	+0.412	.006	2	view →
LUSC	Female	III,IV	−0.314	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

NEFM–COAD

Open the COAD breakdown →