NEFM

Across TCGA cell cohorts, NEFM mutation is significantly associated with the RNA expression of many other genes, with 635 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEFM-associated genes across cancer lineages are C10orf53, KCTD17, and BCL7A. Each is linked with NEFM in more than 1 cancer types. Because this analysis shows association rather than direction, both NEFM-to-partner and partner-to-NEFM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by NEFM-low versus NEFM-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFM→partner) and Y-score (partner→NEFM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	2
LARGE_INTESTINE	KCTD17 →	+0.952	+1.949	<.001	.002	3	2
LARGE_INTESTINE	BCL7A →	+0.780	+2.584	<.001	.002	3	2
LARGE_INTESTINE	EPM2A →	+0.515	+1.949	<.001	.002	3	2
LARGE_INTESTINE	TRIM62 →	+0.383	+1.949	.009	.002	3	2
LARGE_INTESTINE	KCTD1 →	+1.084	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 635 associations by consensus.

C10orf53 by NEFM expression — OESOPHAGUS

Explore this box plot interactively →