NEFL

Across TCGA patient cohorts, NEFL mutation is significantly associated with the RNA expression of many other genes, with 2,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEFL-associated genes across cancer lineages are RN7SL478P, SNAPC2, and DDX41. Each is linked with NEFL in more than 2 cancer types. Because this analysis shows association rather than direction, both NEFL-to-partner and partner-to-NEFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by NEFL-low versus NEFL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFL→partner) and Y-score (partner→NEFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL478P →	+0.234	+4.268	.007	.008	3	3
UCEC	SNAPC2 →	+0.309	+1.818	.007	<.001	3	3
UCEC	DDX41 →	+0.279	+1.958	.002	.002	3	3
SKCM	FAM174C →	+0.514	+3.604	.003	.001	3	3
UCEC	LINC01399 →	+0.114	+1.690	.003	<.001	3	3
CESC	LINC02438 →	+1.497	+3.726	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,713 associations by consensus.

RN7SL478P by NEFL expression — BLCA

Explore this box plot interactively →