NEFH

Across TCGA patient cohorts, NEFH mutation is significantly associated with the RNA expression of many other genes, with 1,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEFH-associated genes across cancer lineages are RNU6-542P, RN7SL553P, and DEFB135. Each is linked with NEFH in more than 2 cancer types. Because this analysis shows association rather than direction, both NEFH-to-partner and partner-to-NEFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-542P grouped by NEFH-low versus NEFH-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFH→partner) and Y-score (partner→NEFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-542P →	+0.219	+4.539	<.001	.008	3	3
COAD	RN7SL553P →	+0.309	+4.070	<.001	.009	3	3
BLCA	DEFB135 →	+0.103	+4.444	<.001	.006	3	3
CESC	SEPTIN7P4 →	+0.088	+6.164	<.001	<.001	3	2
HNSC	UBTFL3 →	+0.079	+7.954	<.001	.008	3	2
HNSC	MIR1179 →	+0.353	+7.954	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,032 associations by consensus.

RNU6-542P by NEFH expression — CESC

Explore this box plot interactively →