NEFH

Across TCGA patient cohorts, NEFH mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEFH-associated genes across cancer lineages are Rictor_pT1135, JNK_pT183_Y185, and MEK1. Each is linked with NEFH in more than 2 cancer types. Because this analysis shows association rather than direction, both NEFH-to-partner and partner-to-NEFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by NEFH-low versus NEFH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFH→partner) and Y-score (partner→NEFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.093	-2.906	.031	.001	3	3
UCEC	JNK_pT183_Y185 →	-0.196	-3.584	.006	.002	3	2
UCEC	MEK1 →	+0.316	+1.700	.041	.044	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.382	-1.687	.045	.044	3	2
UCEC	PDCD4 →	-0.545	-2.449	.006	.019	3	2
UCEC	PKC-delta_pS664 →	-0.106	-2.990	.037	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Rictor_pT1135 by NEFH expression — UCEC

Explore this box plot interactively →