NEFH

Across TCGA cell cohorts, NEFH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,081 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NEFH-associated GO terms across cancer lineages are Postsynaptic intermediate filament cytoskeleton organization, Regulation of telomerase RNA localization to Cajal body, and Neurofilament bundle assembly. Each is linked with NEFH in more than 10 cancer types. Because this analysis shows association rather than direction, both NEFH-to-partner and partner-to-NEFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Postsynaptic intermediate filament cytoskeleton organization grouped by NEFH-low versus NEFH-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFH→partner) and Y-score (partner→NEFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Postsynaptic intermediate filament cytoskeleton organization →	+1.414	+2.557	<.001	<.001	3	11
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.102	+3.380	.006	.002	3	10
BONE	Neurofilament bundle assembly →	+1.721	+3.463	<.001	<.001	3	10
LARGE_INTESTINE	Nucleic acid catabolic process →	+0.038	+0.073	<.001	<.001	3	9
OVARY	Nuclear RNA surveillance →	+0.068	+1.936	<.001	.003	3	8
LUNG_SCLC	Cytokinesis →	+0.079	+2.602	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,081 associations by consensus.

Postsynaptic intermediate filament cytoskeleton organization by NEFH expression — LUNG_NSCLC_LUAD

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