NEDD8

Across TCGA patient cohorts, NEDD8 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEDD8-associated genes across cancer lineages are Cyclin-E2, 4E-BP1_pT37_T46, and INPP4B. Each is linked with NEDD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEDD8-to-partner and partner-to-NEDD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by NEDD8-low versus NEDD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD8→partner) and Y-score (partner→NEDD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.210	+3.000	.030	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.439	-3.000	.043	.037	2	1
UCEC	INPP4B →	-0.468	-2.986	.012	.037	1	1
UCEC	JNK2 →	+0.414	+3.000	<.001	.037	1	1
UCEC	MEK1 →	+0.551	+3.000	.009	.037	1	1
UCEC	PCNA →	+0.406	+3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Cyclin-E2 by NEDD8 expression — UCEC

Explore this box plot interactively →