NEDD8

Across TCGA cell cohorts, NEDD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,877 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NEDD8-associated GO terms across cancer lineages are Protein linear polyubiquitination, Pericentric heterochromatin formation, and Protein insertion into ER membrane by stop-transfer membrane-anchor sequence. Each is linked with NEDD8 in more than 11 cancer types. Because this analysis shows association rather than direction, both NEDD8-to-partner and partner-to-NEDD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein linear polyubiquitination grouped by NEDD8-low versus NEDD8-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD8→partner) and Y-score (partner→NEDD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein linear polyubiquitination →	+0.137	+0.627	.003	<.001	3	12
URINARY_TRACT	Pericentric heterochromatin formation →	+0.115	+0.538	<.001	<.001	3	11
LIVER	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.099	+0.468	.004	.008	2	11
BLOOD_Myeloma	Regulation of mitotic cytokinesis →	+0.163	+1.138	<.001	<.001	3	9
BLOOD_Leukemia	Spliceosomal tri-snRNP complex assembly →	+0.068	+0.673	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	DNA ADP-ribosylation →	+0.162	+0.993	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,877 associations by consensus.

Protein linear polyubiquitination by NEDD8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →