NEDD8

Across TCGA cell cohorts, NEDD8 protein abundance is significantly associated with the RNA expression of many other genes, with 4,052 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible NEDD8-associated genes across cancer lineages are PLPBP, ERH, and LSM1. Each is linked with NEDD8 in more than 7 cancer types. Because this analysis shows association rather than direction, both NEDD8-to-partner and partner-to-NEDD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD8 versus PLPBP in OVARY, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD8→partner) and Y-score (partner→NEDD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLPBP →	+1.078	+1.778	<.001	<.001	3	8
OVARY	ERH →	+0.926	+1.666	.004	<.001	3	7
LARGE_INTESTINE	LSM1 →	+0.724	+1.157	.002	.004	3	7
BONE	GTF2F1 →	+0.826	+1.800	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	VPS33A →	+0.983	+1.651	.003	.002	3	6
OVARY	SNW1 →	+0.615	+1.506	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,052 associations by consensus.

NEDD8 vs PLPBP — OVARY

Explore this scatter interactively →