NEDD4L

Across TCGA pan-cancer cohorts, NEDD4L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NEDD4L data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NEDD4L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NEDD4L expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, COAD, and LUAD are the cancer types where NEDD4L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.423	.005	20	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
LUAD	DFS	Median	All	0.502	0.739	.016	4	view →
LSCC	DFS	Median	II,III,IV	0.821	0.539	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NEDD4L–UCEC (DFS)

Open the UCEC breakdown →