NEDD4

Across TCGA patient cohorts, NEDD4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,577 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NEDD4-associated genes across cancer lineages are RAB31, MSRB3, and VGLL3. Each is linked with NEDD4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD4 versus RAB31 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB31 →	+1.453	+0.603	<.001	<.001	3	7
COAD	MSRB3 →	+1.040	+0.322	<.001	.002	3	7
PDAC	VGLL3 →	+0.737	+0.160	<.001	.008	3	7
OV	EFEMP1 →	+1.730	+0.526	<.001	.001	3	6
COAD	CNN1 →	+1.722	+0.289	<.001	.005	3	6
GBM	RALGPS1 →	-0.695	-0.260	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,577 associations by consensus.

NEDD4 vs RAB31 — OV

Explore this scatter interactively →