NEDD4

Across TCGA patient cohorts, NEDD4 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEDD4-associated genes across cancer lineages are FASN, eIF4E, and 14-3-3_epsilon. Each is linked with NEDD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by NEDD4-low versus NEDD4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FASN →	+0.478	+3.000	.040	.035	3	4
COAD	eIF4E →	+0.177	+2.025	.014	.017	3	2
COAD	14-3-3_epsilon →	+0.104	+2.195	.044	.032	3	2
COAD	Shc_pY317 →	-0.154	-2.983	.023	.034	3	2
COAD	TSC1 →	-0.429	-2.459	<.001	.017	3	2
COAD	ASNS →	+0.652	+2.008	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

FASN by NEDD4 expression — LUAD

Explore this box plot interactively →