NEDD4

Across TCGA cell cohorts, NEDD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,071 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NEDD4-associated GO terms across cancer lineages are Regulation of potassium ion export across plasma membrane, Macroautophagy, and Protein targeting to lysosome. Each is linked with NEDD4 in more than 13 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of potassium ion export across plasma membrane grouped by NEDD4-low versus NEDD4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of potassium ion export across plasma membrane →	+0.272	+1.750	<.001	<.001	3	14
STOMACH	Macroautophagy →	+0.061	+1.467	.003	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein targeting to lysosome →	+0.094	+1.056	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole →	+0.095	+1.160	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to vacuole →	+0.085	+1.194	<.001	<.001	3	11
LIVER	Negative regulation of potassium ion export across plasma membrane →	+0.268	+1.114	<.001	.003	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,071 associations by consensus.

Regulation of potassium ion export across plasma membrane by NEDD4 expression — BONE

Explore this box plot interactively →