NEDD4

Across TCGA cell cohorts, NEDD4 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEDD4-associated genes across cancer lineages are MAGEB5, C5orf52, and GCAT. Each is linked with NEDD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by NEDD4-low versus NEDD4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAGEB5 →	+0.063	+4.432	<.001	.003	3	2
LUNG_SCLC	C5orf52 →	+0.041	+4.058	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.352	+3.321	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.556	+2.451	.003	.009	3	1
LARGE_INTESTINE	OSBP →	+0.751	+3.502	<.001	.001	3	1
LARGE_INTESTINE	HINT3 →	+0.626	+3.502	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

MAGEB5 by NEDD4 expression — STOMACH

Explore this box plot interactively →