NECTIN4

Across TCGA pan-cancer cohorts, NECTIN4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NECTIN4 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NECTIN4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NECTIN4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where NECTIN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	1.000	0.789	.007	12	view →
LSCC	OS	Median	All	1.000	0.936	.008	10	view →
LUAD	OS	Quartile	All	0.877	0.632	.028	4	view →
PDAC	OS	Median	IV	0.231	0.905	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NECTIN4–UCEC (OS)

Open the UCEC breakdown →