NECTIN4

Across TCGA patient cohorts, NECTIN4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,880 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NECTIN4-associated proteins across cancer lineages are S100A11, NECTIN4_S426, and S100A11_S6. Each is linked with NECTIN4 in more than 7 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NECTIN4 versus S100A11 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A11 →	+0.658	+0.391	<.001	<.001	3	8
LSCC	NECTIN4_S426 →	+1.378	+1.635	<.001	<.001	3	7
GBM	S100A11_S6 →	+0.637	+0.332	<.001	.001	3	6
HNSC	GIPC1 →	+0.444	+0.994	<.001	<.001	3	6
OV	GRHL1_T208 →	+1.044	+1.039	.002	.007	2	7
BRCA	LAD1 →	+0.644	+0.604	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,880 associations by consensus.

NECTIN4 vs S100A11 — GBM

Explore this scatter interactively →