NECTIN4

Across TCGA patient cohorts, NECTIN4 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,542 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NECTIN4-associated proteins across cancer lineages are NECTIN4_S426, F11R, and GRHL1_T208. Each is linked with NECTIN4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NECTIN4 versus NECTIN4_S426 in LSCC, with a Pearson correlation of 0.89.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NECTIN4_S426 →	+1.595	+1.063	<.001	<.001	3	7
LSCC	F11R →	+0.485	+0.871	<.001	<.001	3	6
HNSC	GRHL1_T208 →	+0.898	+0.604	<.001	<.001	3	6
BRCA	LAD1 →	+0.978	+0.574	<.001	<.001	3	6
HNSC	ZDHHC5 →	+0.451	+0.514	<.001	<.001	3	6
OV	RAB25 →	+0.950	+0.558	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,542 associations by consensus.

NECTIN4 vs NECTIN4_S426 — LSCC

Explore this scatter interactively →