NECTIN4

Across TCGA patient cohorts, NECTIN4 mutation is significantly associated with the RNA expression of many other genes, with 1,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN4-associated genes across cancer lineages are MRPS5P3, LAP3P2, and IQCF6. Each is linked with NECTIN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5P3 grouped by NECTIN4-low versus NECTIN4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MRPS5P3 →	+0.224	+5.124	<.001	.008	3	3
LUSC	LAP3P2 →	+0.082	+3.097	<.001	<.001	3	3
LUSC	IQCF6 →	+0.106	+2.592	<.001	.004	3	3
UCEC	GHITM →	+0.510	+1.847	.004	.009	3	3
UCEC	RN7SKP286 →	+0.036	+3.668	<.001	.009	3	3
GBM	LINC02745 →	+0.164	+5.352	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,350 associations by consensus.

MRPS5P3 by NECTIN4 expression — HNSC

Explore this box plot interactively →