NECTIN4

Across TCGA patient cohorts, NECTIN4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN4-associated genes across cancer lineages are eEF2, EGFR, and MSH2. Each is linked with NECTIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NECTIN4-low versus NECTIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.319	+2.999	.031	.035	3	2
UCEC	EGFR →	-0.143	-3.000	.030	.036	3	2
UCEC	MSH2 →	-0.348	-3.295	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.277	-2.584	.007	.010	3	1
UCEC	ERK2 →	+0.176	+3.321	.026	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.154	-2.321	.026	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eEF2 by NECTIN4 expression — UCEC

Explore this box plot interactively →