NECTIN4

Across TCGA cell cohorts, NECTIN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,115 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NECTIN4-associated GO terms across cancer lineages are Response to indole-3-methanol, Cellular response to indole-3-methanol, and NMDA selective glutamate receptor signaling pathway. Each is linked with NECTIN4 in more than 12 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by NECTIN4-low versus NECTIN4-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Response to indole-3-methanol →	+0.193	+2.582	<.001	<.001	3	13
PANCREAS	Cellular response to indole-3-methanol →	+0.184	+1.873	<.001	<.001	3	12
STOMACH	NMDA selective glutamate receptor signaling pathway →	+0.303	+1.678	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.193	+2.459	<.001	<.001	3	12
OVARY	Cell-cell adhesion mediated by cadherin →	+0.241	+2.469	<.001	<.001	3	12
STOMACH	Rho protein signal transduction →	+0.113	+2.338	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

Response to indole-3-methanol by NECTIN4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →