NECTIN4-AS1

Across TCGA pan-cancer cohorts, NECTIN4-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated NECTIN4-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NECTIN4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NECTIN4-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUAD show a favorable association.

KIRC, KICH, and LIHC are the cancer types where NECTIN4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.527	0.672	<.001	192	view →
KICH	DFS	Median	All	0.678	0.975	<.001	110	view →
LIHC	DFS	Tertile	All	0.343	0.575	.001	87	view →
MESO	OS	Quartile	All	0.258	0.437	.004	65	view →
KIRP	OS	Quartile	II,III,IV	0.124	0.577	<.001	62	view →
PAAD	OS	Quartile	All	0.291	0.581	.005	27	view →
THYM	OS	Tertile	All	0.854	0.982	<.001	27	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
UCEC	OS	Median	All	0.617	0.731	.019	20	view →
READ	DFS	Quartile	IV	0.362	0.703	.002	20	view →
BRCA	DFS	Median	III,IV	0.834	0.920	.012	14	view →
PCPG	OS	Tertile	All	0.812	0.957	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

NECTIN4-AS1–KIRC (OS)

Open the KIRC breakdown →