NECTIN4-AS1

Across TCGA pan-cancer cohorts, NECTIN4-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NECTIN4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NECTIN4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NECTIN4-AS1 is over-expressed in tumor, although a few such as KIRP and STAD show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where NECTIN4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NECTIN4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.474	<.001	8	view →
THCA	Male	All	+0.259	<.001	8	view →
COAD	Female	IV	+0.165	<.001	7	view →
LUSC	All	All	+0.496	<.001	6	view →
BLCA	Female	III,IV	+0.431	.028	5	view →
BRCA	All	II,III,IV	+0.238	<.001	4	view →
PAAD	All	All	+0.587	.044	2	view →
LUAD	All	All	+0.262	.003	2	view →
CHOL	All	All	+0.226	.008	2	view →
READ	All	II,III,IV	+0.222	.013	2	view →
UCEC	All	All	+0.123	.013	2	view →
KIRP	All	IV	−0.040	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NECTIN4-AS1–HNSC

Open the HNSC breakdown →