NECTIN3

Across TCGA patient cohorts, NECTIN3 mutation is significantly associated with the RNA expression of many other genes, with 1,942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN3-associated genes across cancer lineages are RNA5SP413, MIR1252, and PHKG1P1. Each is linked with NECTIN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NECTIN3-to-partner and partner-to-NECTIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by NECTIN3-low versus NECTIN3-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN3→partner) and Y-score (partner→NECTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNA5SP413 →	+0.340	+5.247	<.001	.006	3	3
CESC	MIR1252 →	+0.456	+4.669	<.001	.007	3	2
BRCA	PHKG1P1 →	+0.059	+4.431	.007	.008	3	2
BRCA	MIR3912 →	+0.478	+3.941	<.001	.005	3	2
UCEC	TXN2P1 →	+0.217	+1.491	.001	.008	3	2
UCEC	RNA5SP158 →	+0.100	+2.879	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,942 associations by consensus.

RNA5SP413 by NECTIN3 expression — ESCA

Explore this box plot interactively →