NECTIN3-AS1

Across TCGA pan-cancer cohorts, NECTIN3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NECTIN3-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NECTIN3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NECTIN3-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

UCS, ACC, and KICH are the cancer types where NECTIN3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	II,III,IV	0.890	0.346	.002	68	view →
ACC	DFS	Tertile	All	0.350	0.875	<.001	65	view →
KICH	DFS	Tertile	II,III,IV	0.541	0.944	.008	52	view →
LGG	DFS	Median	All	0.485	0.323	<.001	38	view →
UVM	DFS	Median	All	0.920	0.592	.001	36	view →
HNSC	OS	Quartile	All	0.356	0.499	.016	31	view →
CESC	OS	Tertile	II,III,IV	0.743	0.888	.028	30	view →
UCEC	DFS	Quartile	III,IV	0.738	0.900	.003	30	view →
READ	OS	Tertile	All	0.599	1.000	.004	19	view →
LIHC	DFS	Median	All	0.280	0.556	<.001	19	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	17	view →
KIRC	DFS	Tertile	All	0.865	0.691	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NECTIN3-AS1–UCS (DFS)

Open the UCS breakdown →