NECTIN3-AS1

Across TCGA pan-cancer cohorts, NECTIN3-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NECTIN3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NECTIN3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NECTIN3-AS1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and BRCA are the cancer types where NECTIN3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NECTIN3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.662	<.001	10	view →
UCEC	All	All	−0.340	<.001	6	view →
BRCA	All	III,IV	−0.288	<.001	6	view →
READ	All	All	−0.296	.004	3	view →
KIRC	All	II,III,IV	−0.128	.004	3	view →
LIHC	All	All	+0.109	.009	3	view →
COAD	All	III,IV	−0.124	.003	2	view →
HNSC	All	II,III,IV	+0.090	.025	2	view →
LUAD	All	All	+0.240	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NECTIN3-AS1–THCA

Open the THCA breakdown →