NECTIN1

Across TCGA patient cohorts, NECTIN1 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,469 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NECTIN1-associated proteins across cancer lineages are NECTIN1_S422, ARHGAP25, and STK10_S438. Each is linked with NECTIN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both NECTIN1-to-partner and partner-to-NECTIN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NECTIN1 versus NECTIN1_S422 in LSCC, with a Pearson correlation of 0.90.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN1→partner) and Y-score (partner→NECTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NECTIN1_S422 →	+0.998	+0.822	<.001	<.001	3	8
UCEC	ARHGAP25 →	-0.572	-0.485	<.001	<.001	3	5
OV	STK10_S438 →	-0.640	-0.433	<.001	<.001	3	5
GBM	PLXNB1 →	+0.322	+0.487	<.001	<.001	3	5
HNSC	SLC7A8 →	+0.811	+0.407	<.001	<.001	3	5
UCEC	GIT2 →	-0.240	-0.517	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,469 associations by consensus.

NECTIN1 vs NECTIN1_S422 — LSCC

Explore this scatter interactively →