NECTIN1

Across TCGA patient cohorts, NECTIN1 mutation is significantly associated with the RNA expression of many other genes, with 5,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECTIN1-associated genes across cancer lineages are IGHD3-10, TRAJ47, and TNPO1P2. Each is linked with NECTIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NECTIN1-to-partner and partner-to-NECTIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-10 grouped by NECTIN1-low versus NECTIN1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN1→partner) and Y-score (partner→NECTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGHD3-10 →	+1.904	+3.892	<.001	.001	3	3
UCEC	TRAJ47 →	+0.334	+1.575	<.001	.006	3	3
UCEC	TNPO1P2 →	+0.032	+1.528	.004	.001	3	3
CESC	NANOGP6 →	+0.078	+4.539	<.001	.008	3	2
UCEC	IGLV2-8 →	+1.273	+2.098	.001	.002	3	2
UCEC	LINC02550 →	-0.444	-3.857	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,884 associations by consensus.

IGHD3-10 by NECTIN1 expression — LUAD

Explore this box plot interactively →