NECAP2

Across TCGA patient cohorts, NECAP2 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECAP2-associated genes across cancer lineages are RN7SL248P, RPL12P3, and MIR3612. Each is linked with NECAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECAP2-to-partner and partner-to-NECAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NECAP2-low versus NECAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECAP2→partner) and Y-score (partner→NECAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.102	+4.137	<.001	.008	3	2
READ	RPL12P3 →	+0.250	+7.276	<.001	<.001	3	2
UCEC	MIR3612 →	+0.398	+3.450	.001	.005	3	2
UCEC	TRDV2 →	+0.175	+3.193	<.001	.004	3	2
COAD	MIR302D →	+0.740	+4.577	.002	.004	3	2
CESC	LCN1P2 →	+0.180	+5.569	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

RN7SL248P by NECAP2 expression — UCEC

Explore this box plot interactively →