NECAB3

Across TCGA patient cohorts, NECAB3 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECAB3-associated genes across cancer lineages are RNU6-539P, RNU6-1191P, and RNU4-63P. Each is linked with NECAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECAB3-to-partner and partner-to-NECAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-539P grouped by NECAB3-low versus NECAB3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECAB3→partner) and Y-score (partner→NECAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-539P →	+0.565	+3.611	.004	.001	3	2
CESC	RNU6-1191P →	+0.530	+5.103	<.001	.008	3	2
SKCM	RNU4-63P →	+0.424	+6.797	<.001	<.001	3	1
SKCM	IPPKP1 →	+0.078	+5.224	<.001	.007	3	1
UCEC	GRIK4 →	-0.464	-2.906	.009	.002	3	1
UCEC	TMEM251 →	+0.656	+4.010	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

RNU6-539P by NECAB3 expression — COAD

Explore this box plot interactively →