NECAB3

Across TCGA pan-cancer cohorts, NECAB3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NECAB3 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NECAB3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NECAB3 expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

KIRC, UCEC, and KICH are the cancer types where NECAB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.592	0.737	.003	67	view →
UCEC	DFS	Tertile	All	0.771	0.894	<.001	60	view →
KICH	DFS	Median	III,IV	0.297	1.000	.002	48	view →
THYM	OS	Median	All	0.766	1.000	.002	45	view →
LIHC	DFS	Tertile	All	0.488	0.654	.002	22	view →
COAD	DFS	Quartile	IV	0.279	0.840	.005	21	view →
MESO	OS	Quartile	All	0.552	0.269	.005	18	view →
BLCA	DFS	Quartile	III,IV	0.283	0.603	.004	15	view →
ESCA	DFS	Quartile	III,IV	0.294	0.606	.006	15	view →
SKCM	OS	Median	IV	0.221	0.780	.004	12	view →
OV	OS	Tertile	All	0.813	0.884	.010	12	view →
HNSC	OS	Median	IV	0.662	0.539	.020	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NECAB3–KIRC (DFS)

Open the KIRC breakdown →