NECAB3

Across TCGA patient cohorts, NECAB3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NECAB3-associated genes across cancer lineages are EGFR_pY1068, Notch1, and p27_pT198. Each is linked with NECAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECAB3-to-partner and partner-to-NECAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NECAB3-low versus NECAB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECAB3→partner) and Y-score (partner→NECAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-2.807	.029	.003	3	1
UCEC	Notch1 →	+0.214	+2.472	<.001	.010	3	1
UCEC	p27_pT198 →	+0.132	+2.999	.004	.035	3	1
UCEC	PCNA →	+0.229	+2.999	.015	.035	3	1
UCEC	ATM →	-0.493	-2.986	.012	.035	3	1
UCEC	MEK1 →	+0.473	+2.807	.003	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by NECAB3 expression — UCEC

Explore this box plot interactively →