NEBL

Across TCGA patient cohorts, NEBL mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEBL-associated genes across cancer lineages are Cyclin-B1, PDCD4, and VHL. Each is linked with NEBL in more than 3 cancer types. Because this analysis shows association rather than direction, both NEBL-to-partner and partner-to-NEBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NEBL-low versus NEBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEBL→partner) and Y-score (partner→NEBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.555	+2.247	<.001	.001	3	4
UCEC	PDCD4 →	-0.370	-1.584	.003	.015	3	3
UCEC	VHL →	-0.760	-1.754	<.001	<.001	3	3
UCEC	p27_pT157 →	-0.041	-1.146	.008	.011	3	3
UCEC	TFRC →	+0.412	+1.146	.003	.011	3	3
UCEC	CDK1 →	+0.116	+1.527	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Cyclin-B1 by NEBL expression — UCEC

Explore this box plot interactively →