NEBL

Across TCGA pan-cancer cohorts, NEBL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NEBL data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NEBL RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NEBL expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, BLCA, and OV are the cancer types where NEBL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.752	0.509	<.001	142	view →
BLCA	DFS	Tertile	II,III,IV	0.257	0.436	<.001	100	view →
OV	OS	Quartile	II,III,IV	0.773	0.888	.003	70	view →
LUAD	DFS	Tertile	II,III,IV	0.200	0.607	.001	33	view →
PAAD	OS	Quartile	II,III,IV	0.266	0.506	<.001	21	view →
KIRP	DFS	Median	All	0.946	0.874	.013	21	view →
UVM	OS	Tertile	III,IV	0.353	0.920	.015	18	view →
PRAD	DFS	Median	All	0.963	0.902	.002	18	view →
THYM	DFS	Tertile	All	1.000	0.695	.021	15	view →
THCA	OS	Quartile	II,III,IV	0.706	0.958	.006	15	view →
LIHC	OS	Tertile	III,IV	0.842	0.376	.004	14	view →
ACC	DFS	Median	All	0.542	0.773	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NEBL–KIRC (DFS)

Open the KIRC breakdown →