NEBL-AS1

Across TCGA pan-cancer cohorts, NEBL-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NEBL-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NEBL-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEBL-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where NEBL-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEBL-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.380	<.001	11	view →
KICH	Male	All	−2.196	<.001	10	view →
LUAD	Female	III,IV	−0.952	<.001	9	view →
KIRP	All	All	−1.067	<.001	7	view →
COAD	All	All	+0.479	<.001	6	view →
KIRC	All	II,III,IV	−0.599	<.001	5	view →
BLCA	All	III,IV	+0.817	.003	4	view →
LUSC	Male	All	−0.397	.009	3	view →
CHOL	Female	All	+2.133	.012	2	view →
LIHC	Female	All	+0.274	.037	2	view →
STAD	All	IV	−0.400	.026	1	view →
LIHC	Male	III,IV	−0.145	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

NEBL-AS1–THCA

Open the THCA breakdown →