NEB

Across TCGA pan-cancer cohorts, NEB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NEB data layer compared with 24 for mass-spec protein and 14 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NEB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NEB expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where NEB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.850	0.333	.004	20	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	16	view →
LUAD	OS	Tertile	All	0.888	0.702	.016	5	view →
HNSC	DFS	Median	III,IV	0.885	0.723	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NEB–UCEC (DFS)

Open the UCEC breakdown →