NDUFS6

Across TCGA pan-cancer cohorts, NDUFS6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDUFS6 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFS6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDUFS6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where NDUFS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.565	0.269	.001	40	view →
HNSC	DFS	Quartile	II,III,IV	0.812	1.000	.001	25	view →
CCRCC	DFS	Median	IV	0.861	0.131	.001	18	view →
GBM	DFS	Quartile	All	0.860	0.558	.012	8	view →
LUAD	DFS	Tertile	II,III,IV	0.681	0.334	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDUFS6–PDAC (DFS)

Open the PDAC breakdown →