NDUFS6

Across TCGA pan-cancer cohorts, NDUFS6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NDUFS6’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NDUFS6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDUFS6 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LIHC, LUAD, and LUSC are the cancer types where NDUFS6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFS6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.216	<.001	9	view →
LUAD	Female	III,IV	+0.978	<.001	9	view →
LUSC	Female	All	+1.486	<.001	8	view →
UCEC	All	II,III,IV	+0.857	<.001	8	view →
HNSC	Male	III,IV	+0.816	<.001	8	view →
STAD	All	II,III,IV	+0.670	<.001	6	view →
BRCA	All	All	+0.490	<.001	6	view →
COAD	Female	All	+0.623	<.001	5	view →
CHOL	Male	All	+1.223	<.001	2	view →
KIRC	Male	All	−0.280	.023	2	view →
ESCA	All	All	+0.740	.012	1	view →
KICH	All	All	−0.346	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NDUFS6–LIHC

Open the LIHC breakdown →