NDUFS2

Across TCGA pan-cancer cohorts, NDUFS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDUFS2 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFS2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDUFS2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where NDUFS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.556	0.234	.009	22	view →
CCRCC	OS	Tertile	All	1.000	0.885	.012	14	view →
HNSC	DFS	Quartile	II,III,IV	0.854	0.983	.023	4	view →
GBM	DFS	Median	All	0.783	0.650	.036	2	view →
LUAD	DFS	Tertile	III,IV	0.805	0.475	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDUFS2–PDAC (OS)

Open the PDAC breakdown →