NDUFS2

Across TCGA pan-cancer cohorts, NDUFS2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NDUFS2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NDUFS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDUFS2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

BLCA, LIHC, and LUAD are the cancer types where NDUFS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	III,IV	+0.657	<.001	10	view →
LIHC	Male	All	+1.081	<.001	9	view →
LUAD	Male	All	+0.566	<.001	9	view →
LUSC	Female	All	+0.861	<.001	8	view →
KIRC	Male	II,III,IV	−0.660	<.001	8	view →
THCA	All	All	−0.223	<.001	8	view →
STAD	All	II,III,IV	+0.421	<.001	7	view →
COAD	All	All	−0.294	<.001	7	view →
BRCA	All	III,IV	+0.729	<.001	6	view →
KIRP	Male	All	−0.555	<.001	6	view →
KICH	All	All	−0.479	<.001	5	view →
CHOL	All	All	+1.157	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NDUFS2–BLCA

Open the BLCA breakdown →