NDUFS2

Across TCGA patient cohorts, NDUFS2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFS2-associated genes across cancer lineages are mTOR_pS2448, p70-S6K, and RAD51. Each is linked with NDUFS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFS2-to-partner and partner-to-NDUFS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by NDUFS2-low versus NDUFS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS2→partner) and Y-score (partner→NDUFS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.109	-1.687	.035	.040	3	2
UCEC	p70-S6K →	+0.152	+1.505	.023	.034	3	2
UCEC	RAD51 →	+0.099	+2.222	.041	.010	3	2
UCEC	VHL →	-0.689	-2.000	.003	.029	3	2
UCEC	c-Met_pY1235 →	+0.061	+1.440	.018	.024	3	2
UCEC	Cyclin-D1 →	+0.156	+1.440	.005	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

mTOR_pS2448 by NDUFS2 expression — UCEC

Explore this box plot interactively →