NDUFS1

Across TCGA pan-cancer cohorts, NDUFS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFS1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFS1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDUFS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where NDUFS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.656	0.317	.004	16	view →
HNSC	DFS	Tertile	All	1.000	0.317	.028	12	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.749	.011	8	view →
GBM	OS	Median	All	0.881	0.748	.004	3	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.321	.006	3	view →
UCEC	DFS	Median	All	0.917	0.791	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFS1–PDAC (OS)

Open the PDAC breakdown →