NDUFS1

Across TCGA pan-cancer cohorts, NDUFS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NDUFS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NDUFS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NDUFS1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where NDUFS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.567	<.001	10	view →
COAD	All	All	−0.432	<.001	10	view →
KIRC	Male	All	−0.979	<.001	9	view →
LUAD	Male	II,III,IV	+0.687	<.001	9	view →
KICH	All	II,III,IV	−0.821	<.001	8	view →
KIRP	Male	All	−0.520	.006	3	view →
READ	All	II,III,IV	−0.505	.024	2	view →
HNSC	Male	All	−0.435	.010	2	view →
LUSC	All	All	+0.333	<.001	2	view →
LIHC	All	All	+0.309	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NDUFS1–THCA

Open the THCA breakdown →