NDUFS1

Across TCGA patient cohorts, NDUFS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFS1-associated genes across cancer lineages are Cyclin-B1, GAPDH, and Tuberin_pT1462. Each is linked with NDUFS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NDUFS1-to-partner and partner-to-NDUFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NDUFS1-low versus NDUFS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS1→partner) and Y-score (partner→NDUFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.475	+2.321	.011	.005	3	3
UCEC	GAPDH →	+0.490	+1.584	.006	.009	3	2
UCEC	Tuberin_pT1462 →	+0.182	+1.594	.018	.021	3	2
UCEC	4E-BP1 →	+0.261	+1.874	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.218	-3.459	.009	.005	3	1
UCEC	EGFR →	-0.114	-2.295	.032	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-B1 by NDUFS1 expression — UCEC

Explore this box plot interactively →