NDUFS1

Across TCGA cell cohorts, NDUFS1 mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NDUFS1-associated genes across cancer lineages are Methotrexate, CDK9_5576, and Cytarabine. Each is linked with NDUFS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFS1-to-partner and partner-to-NDUFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methotrexate grouped by NDUFS1-low versus NDUFS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS1→partner) and Y-score (partner→NDUFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Methotrexate →	+1.070	+2.807	.005	.046	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.504	+2.871	.042	.021	3	1
LARGE_INTESTINE	Cytarabine →	+0.787	+2.655	.043	.044	1	1
LARGE_INTESTINE	5-Fluorouracil →	+0.618	+2.991	.024	.018	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.453	+2.871	.015	.021	1	1
LARGE_INTESTINE	PAK_5339 →	+0.371	+2.871	.007	.021	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Methotrexate by NDUFS1 expression — LARGE_INTESTINE

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