NDUFC1

Across TCGA pan-cancer cohorts, NDUFC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDUFC1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NDUFC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

HNSC, LUAD, and OV are the cancer types where NDUFC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.664	0.905	.003	20	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	10	view →
OV	DFS	Quartile	All	0.965	0.594	.045	8	view →
GBM	DFS	Quartile	All	0.868	0.525	.003	7	view →
LSCC	DFS	Median	II,III,IV	0.988	0.842	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDUFC1–HNSC (DFS)

Open the HNSC breakdown →