NDUFC1

Across TCGA pan-cancer cohorts, NDUFC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NDUFC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NDUFC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDUFC1 is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where NDUFC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.329	<.001	11	view →
LIHC	Female	II,III,IV	+0.613	<.001	7	view →
KIRP	All	All	−0.466	<.001	7	view →
COAD	All	All	−0.345	<.001	7	view →
HNSC	All	All	−0.252	.001	5	view →
THCA	All	All	−0.217	.004	5	view →
BRCA	All	All	+0.187	.001	4	view →
CHOL	All	All	+0.746	.002	2	view →
READ	All	All	−0.739	.005	2	view →
LUSC	Female	II,III,IV	+0.564	.040	1	view →
KICH	All	All	−0.327	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NDUFC1–KIRC

Open the KIRC breakdown →